Colchicine in the Therapy of Cardiovascular Disease: The Bulgarian Contribution

The saga of Colchicum autumnale (commonly known as autumn crocus, meadow saffron or naked ladies), from which colchicine was extracted, has been around for some 3 000 years, as described by ancient writers as the remedy of choice for gout patients suffering debilitating pain due to acute arthritis. Today, this therapeutic effect is known to be due to its anti-inflammatory action. However, in the last 30-40 years colchicine has also been used to treat familial Mediterranean fever (and related amyloidosis and recurrent pericarditis), Behçet's disease, acute febrile neutrophilic dermatosis (Sweet's syndrome), epidermolysis bullosa acquisita, leukocytoclastic vasculitis, aphthous stomatitis, also liver cirrhosis, scleroderma and other fibro-inflammatory diseases.

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